Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM002036)
DM Name	5-OH-fluvastatin

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 2C8 (CYP2C8)	DME0018	Fluvastatin sodium	Oxidation - Hydroxylation	Fluvastatin sodium	[1] , [2] , [3]
Cytochrome P450 2C9 (CYP2C9)	DME0019	Fluvastatin sodium	Oxidation - Hydroxylation	Fluvastatin sodium	[1] , [2] , [3]
Cytochrome P450 2D6 (CYP2D6)	DME0009	Fluvastatin sodium	Oxidation - Hydroxylation	Fluvastatin sodium	[1] , [2] , [3]
Cytochrome P450 3A4 (CYP3A4)	DME0001	Fluvastatin sodium	Oxidation - Hydroxylation	Fluvastatin sodium	[1] , [2] , [3]

Full List of Drug(s) That Produce This DM By Metabolism
Fluvastatin sodium		DR0738	Approved		Hypertriglyceridaemia

References
1	Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2	Metabolism and transport of oxazaphosphorines and the clinical implications Drug Metab Rev. 2005;37(4):611-703. doi: 10.1080/03602530500364023.
3	Assessment of ifosfamide pharmacokinetics, toxicity, and relation to CYP3A4 activity as measured by the erythromycin breath test in patients with sarcoma Cancer. 2007 Jun 1;109(11):2315-22. doi: 10.1002/cncr.22669.

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