| General Information of Drug Metabolite (DM) (ID: DM002290) |
| DM Name |
Olaparib metabolite M12
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| Structure |
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3D MOL is unavailable
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2D MOL is unavailable
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 3A4 (CYP3A4)
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DME0001
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| Oxidation - Alcohol Oxidation |
Olaparib
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[1] |
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Cytochrome P450 3A5 (CYP3A5)
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DME0012
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| Oxidation - Alcohol Oxidation |
Olaparib
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Olaparib |
DR1188
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Approved |
Ovarian cancer |
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| References |
| 1 |
In vitro metabolism of olaparib in liver microsomes by liquid chromatography/electrospray ionization high-resolution mass spectrometry Rapid Commun Mass Spectrom. 2020 Feb 15;34(3):e8575. doi: 10.1002/rcm.8575.
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