General Information of Drug Metabolite (DM) (ID: DM017811)
DM Name
TAK-802 Metabolite M-IV
Structure
3D MOL is unavailable 2D MOL is unavailable
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DME0199 Reduction - Reduction TAK-802 [1]
DME(s) Metabolizing This DM
DME Name DME ID Product Reaction Related Drug REF
Cytochrome P450 2B6 (CYP2B6) DME0020 Unclear - Unclear TAK-802 [1]
Cytochrome P450 2E1 (CYP2E1) DME0013 Unclear - Unclear TAK-802 [1]
Cytochrome P450 3A4 (CYP3A4) DME0001 Unclear - Unclear TAK-802 [1]
Full List of Drug(s) That Produce This DM By Metabolism
TAK-802 DR2997 Discontinued in Phase 2 Urinary dysfunction
References
1 Main metabolic pathways of TAK-802, a novel drug candidate for voiding dysfunction, in humans: the involvement of carbonyl reduction by 11-hydroxysteroid dehydrogenase 1

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