Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR1100)
Drug Name
KAD-1229
Synonyms
Mitiglinide [INN]; PubChem23270; SB19330; TL8001004; WPGGHFDDFPHPOB-BBWFWOEESA-N; ZINC1482913; (2S)-4-[(3aR,7aS)-1,3,3a,4,5,6,7,7a-octahydroisoindol-2-yl]-2-benzyl-4-oxobutanoic acid; 145375-43-5; 2(S)-cis-Octahydro-gamma-oxo-alpha-(phenylmethyl)-2H-isoindole-2-butanoic acid; 525M413; AC-632; AC1L3TLA; AJ-64505; AKOS025149480; API0024507; CHEBI:135349; CHEMBL471498; DB01252; DTXSID4048303; MFCD08458378; D86I0XLB13; SCHEMBL49085; UNII-D86I0XLB13
Indication Diabetes mellitus [ICD11: 5A10] Phase 3 [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 315.4 Topological Polar Surface Area 57.6
Heavy Atom Count 23 Rotatable Bond Count 5
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 3
Cross-matching ID
PubChem CID
121891
PubChem SID
14923600 ; 14923601 ; 23920047 ; 29302386 ; 49831004 ; 50245159 ; 57339829 ; 92719299 ; 103587862 ; 104179015 ; 104414523 ; 126628276 ; 129614266 ; 135133781 ; 137005782 ; 140502366 ; 143496772 ; 152234170 ; 180372013 ; 198946246 ; 223573676 ; 224246809 ; 226432923 ; 252359550 ; 252671987
ChEBI ID
CHEBI:135349
CAS Number
145375-43-5
TTD Drug ID
D0P2YU
Formula
C19H25NO3
Canonical SMILES
C1CCC2CN(CC2C1)C(=O)CC(CC3=CC=CC=C3)C(=O)O
InChI
1S/C19H25NO3/c21-18(20-12-15-8-4-5-9-16(15)13-20)11-17(19(22)23)10-14-6-2-1-3-7-14/h1-3,6-7,15-17H,4-5,8-13H2,(H,22,23)/t15-,16+,17-/m0/s1
InChIKey
WPGGHFDDFPHPOB-BBWFWOEESA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Mitiglinide carboxyl-glucuronide DM003245 N. A. Conjugation - Conjugation 1 [4]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR003683 KAD-1229 Mitiglinide carboxyl-glucuronide Conjugation - Conjugation UGT1A3 ... [4]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME0004 Homo sapiens
UD11_HUMAN
2.4.1.17
[2]
UDP-glucuronosyltransferase 1A3 (UGT1A3) DME0041 Homo sapiens
UD13_HUMAN
2.4.1.17
[3]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME0040 Homo sapiens
UD2B7_HUMAN
2.4.1.17
[4]
References
1 ClinicalTrials.gov (NCT00461617) Double-Blind Comparison Between Mitiglinide and Nateglinide in Type 2 Diabetic Patients.
2 Carboxyl-glucuronidation of mitiglinide by human UDP-glucuronosyltransferases. Biochem Pharmacol. 2007 Jun 1;73(11):1842-51.
3 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
4 Mitiglinide: a rapid- and short-acting non-sulfonylurea insulinotropic agent for the treatment of type 2 diabetic patients

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