Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2135)
Drug Name
Uridine
Synonyms
Uracil riboside; Uracil, 1-beta-D-ribofuranosyl-; DRTQHJPVMGBUCF-XVFCMESISA-N; Uracil-1-beta-d-ribofuranoside; Uridin; WHI7HQ7H85; b-Uridine; beta-Uridine; d-uridine; uridine; uridine-1'-13C; 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 1-.beta.-D-Ribofuranosyluracil; 1-beta-D-Ribofuranosyluracil; 58-96-8; AI3-52690; C9H12N2O6; CHEBI:16704; EINECS 200-407-5; MFCD00006526; MLS000069625; NSC 20256; SMR000058222; UNII-WHI7HQ7H85; Urd
Indication Depression [ICD11: 6A71] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 244.2 Topological Polar Surface Area 119
Heavy Atom Count 17 Rotatable Bond Count 2
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 6
Cross-matching ID
PubChem CID
6029
PubChem SID
3275 ; 3593 ; 584045 ; 825827 ; 3134852 ; 3718411 ; 7891023 ; 8139953 ; 8144667 ; 8153756 ; 12109174 ; 14710325 ; 14847540 ; 15221017 ; 24900434 ; 24900638 ; 24900640 ; 26702452 ; 26715956 ; 26754144 ; 29225043 ; 46167442 ; 46391419 ; 46504323 ; 48095962 ; 49833656 ; 50059626 ; 56459453 ; 57323128 ; 77021584 ; 81044517 ; 81092927 ; 85164984 ; 85230753 ; 87577750 ; 88835504 ; 92298506 ; 99226784 ; 99438033 ; 103313732 ; 103852268 ; 104310914 ; 117358157 ; 117613647 ; 118048883 ; 123059964 ; 124525105 ; 124799625 ; 124882993 ; 126523145
ChEBI ID
ChEBI:16704
CAS Number
322-35-0
TTD Drug ID
D0Y7DP
Formula
C9H12N2O6
Canonical SMILES
C1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)O
InChI
1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1
InChIKey
DRTQHJPVMGBUCF-XVFCMESISA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
UMP DM002411
6030
Unclear 1 [4]
Uracil DM002419
1174
Unclear 1 [4]
Beta-alanine DM002420
239
Unclear 2 [4]
UDP DM002412
6031
Unclear 2 [4]
DNA DM002418 N. A. Unclear 3 [4] , [5] , [6]
UTP DM002413
6133
Unclear 3 [4]
CTP DM002414 N. A. Unclear 4 [4] , [7] , [8]
RNA DM002417 N. A. Unclear 4 [4] , [9] , [6]
UDP-sugars DM002416 N. A. Unclear 4 [4]
CTP-lipids DM002415 N. A. Unclear 5 [4]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR002481 Uridine UMP Unclear Unclear [4]
MR002482 Uridine Uracil Unclear Unclear [4]
MR002473 UMP UDP Unclear Unclear [4]
MR002480 Uracil Beta-alanine Unclear Unclear [4]
MR002474 UDP UTP Unclear Unclear [4]
MR002475 UDP DNA Unclear Unclear [4], [5], [6]
MR002476 UTP CTP Unclear Unclear [4], [7], [8]
MR002477 UTP UDP-sugars Unclear Unclear [4]
MR002478 UTP RNA Unclear Unclear [4], [9], [6]
MR002479 CTP CTP-lipids Unclear Unclear [4]
⏷ Show the Full List of 10 MR(s)
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Nicotinamide riboside kinase 1 (NRK1) DME0479 Homo sapiens
NRK1_HUMAN
2.7.1.22
[2]
Nicotinamide riboside kinase 2 (NRK2) DME0478 Homo sapiens
NRK2_HUMAN
2.7.1.22
[2]
Uridine-cytidine kinase 1 (UCK1) DME0481 Homo sapiens
UCK1_HUMAN
2.7.1.48
[3]
Uridine-cytidine kinase 2 (UCK2) DME0480 Homo sapiens
UCK2_HUMAN
2.7.1.48
[3]
Experimental Enzyme Kinetic Data of This Drug
DME Name DME Info Kinetic Data Uniprot ID REF
Nicotinamide riboside kinase 1 (NRK1) DME0479 Km = 1.3 microM
NRK1_HUMAN
[2]
Nicotinamide riboside kinase 2 (NRK2) DME0478 Km = 1.3 microM
NRK2_HUMAN
[2]
Uridine-cytidine kinase 1 (UCK1) DME0481 Km = 0.05 microM
UCK1_HUMAN
[3]
Uridine-cytidine kinase 2 (UCK2) DME0480 Km = 0.05 microM
UCK2_HUMAN
[3]
References
1 Uridine was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 Nicotinamide riboside kinase structures reveal new pathways to NAD+. PLoS Biol. 2007 Oct 2;5(10):e263.
3 Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases. Mol Pharmacol. 2001 May;59(5):1181-6.
4 Uridine and its nucleotides: biological actions, therapeutic potentials Trends Pharmacol Sci. 1999 May;20(5):218-25. doi: 10.1016/s0165-6147(99)01298-5.
5 Differential roles of CTP synthetases CTPS1 and CTPS2 in cell proliferation. Life Sci Alliance. 2023 Jun 22;6(9):e202302066. doi: 10.26508/lsa.202302066. Print 2023 Sep.
6 Uridine Inhibits Hepatocellular Carcinoma Cell Development by Inducing Ferroptosis. J Clin Med. 2023 May 18;12(10):3552. doi: 10.3390/jcm12103552.
7 Computational assessment of Withania somnifera phytomolecules as putative inhibitors of Mycobacterium tuberculosis CTP synthase PyrG. J Biomol Struct Dyn. 2023 Jul;41(11):4903-4916. doi: 10.1080/07391102.2022.2074142.
8 Structural basis for ligand binding modes of CTP synthase. Proc Natl Acad Sci U S A. 2021 Jul 27;118(30):e2026621118. doi: 10.1073/pnas.2026621118.
9 Decoding the 'Fifth' Nucleotide: Impact of RNA Pseudouridylation on Gene Expression and Human Disease. Mol Biotechnol. 2023 Jun 21. doi: 10.1007/s12033-023-00792-1.

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