Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR5977)
Drug Name
Maribavir
Synonyms
176161-24-3; Benzimidavir; (2S,3S,4R,5S)-2-(5,6-dichloro-2-(isopropylamino)-1H-benzo[d]imidazol-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol; 1263W94; UNII-PTB4X93HE1; PTB4X93HE1; 5,6-Dichloro-2-(isopropylamino)-1-(beta-L-ribofuranosyl)-1H-benzimidazole; 5,6-Dichloro-N-(1-methylethyl)-1-beta-L-ribofuranosyl-1H-benzimidazol-2-amine; (2S,3S,4R,5S)-2-[5,6-dichloro-2-(propan-2-ylamino)benzimidazol-1-yl]-5-(hydroxymethyl)oxolane-3,4-diol; Maribavir [USAN:INN:BAN]; Camvia; C15H19Cl2N3O4; Camvia(TM); Camvia (TN); Bzurea
Indication Cytomegalovirus infection [ICD11: 1D82] Phase 3 [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 376.2 Topological Polar Surface Area 99.8
Heavy Atom Count 24 Rotatable Bond Count 4
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 6
Cross-matching ID
PubChem CID
471161
CAS Number
176161-24-3
TTD Drug ID
D07WXI
Formula
C15H19Cl2N3O4
Canonical SMILES
CC(C)NC1=NC2=CC(=C(C=C2N1[C@@H]3[C@H]([C@H]([C@@H](O3)CO)O)O)Cl)Cl
InChI
InChI=1S/C15H19Cl2N3O4/c1-6(2)18-15-19-9-3-7(16)8(17)4-10(9)20(15)14-13(23)12(22)11(5-21)24-14/h3-4,6,11-14,21-23H,5H2,1-2H3,(H,18,19)/t11-,12-,13-,14-/m0/s1
InChIKey
KJFBVJALEQWJBS-XUXIUFHCSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Maribavir M10 DM005105 N. A. Conjugation - Glucuronidation conjugation 1 [3]
Maribavir M15 DM005104 N. A. Multi-steps Reaction - Dechlorination; glutathione (GSH) conjugation; amide hydrolysis 1 [3]
Maribavir M2 DM005103 N. A. Multi-steps Reaction - Glucuronidation conjugation; deribosylation 1 [3]
Maribavir M5 DM005102 N. A. Oxidation - Oxidationn 1 [3]
VP 44469 DM005100
53794264
Oxidation - N-Dealkylation 1 [2]
Maribavir M1 DM005101 N. A. Conjugation - Glucuronidation conjugation 2 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR005532 Maribavir VP 44469 Oxidation - N-Dealkylation CYP3A4 ... [2]
MR005534 Maribavir Maribavir M5 Oxidation - Oxidationn Unclear [3]
MR005535 Maribavir Maribavir M2 Multi-steps Reaction - Glucuronidation conjugation; deribosylation Unclear [3]
MR005536 Maribavir Maribavir M15 Multi-steps Reaction - Dechlorination; glutathione (GSH) conjugation; amide hydrolysis Unclear [3]
MR005537 Maribavir Maribavir M10 Conjugation - Glucuronidation conjugation Unclear [3]
MR005533 VP 44469 Maribavir M1 Conjugation - Glucuronidation conjugation Unclear [3]
⏷ Show the Full List of 6 MR(s)
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 1A2 (CYP1A2) DME0003 Homo sapiens
CP1A2_HUMAN
1.14.14.1
[2]
Cytochrome P450 3A4 (CYP3A4) DME0001 Homo sapiens
CP3A4_HUMAN
1.14.14.55
[2]
References
1 ClinicalTrials.gov (NCT00497796) Maribavir Versus Oral Ganciclovir For The Prevention of Cytomegalovirus (CMV) Disease in Liver Transplant Recipients. U.S. National Institutes of Health.
2 Effect of ketoconazole on the pharmacokinetics of maribavir in healthy adults
3 Elucidation of Metabolic and Disposition Pathways for Maribavir in Nonhuman Primates through Mass Balance and Semi-Physiologically Based Modeling Approaches

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