Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005532)
Formula
CYP3A4 ...
SVG example
N-Dealkylation
Reactant Maribavir Product VP 44469
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Metabolic Type Oxidation - N-Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005537 Maribavir Maribavir M10 Conjugation - Glucuronidation conjugation Maribavir [1]
MR005536 Maribavir Maribavir M15 Multi-steps Reaction - Dechlorination; glutathione (GSH) conjugation; amide hydrolysis Maribavir [1]
MR005535 Maribavir Maribavir M2 Multi-steps Reaction - Glucuronidation conjugation; deribosylation Maribavir [1]
MR005534 Maribavir Maribavir M5 Oxidation - Oxidationn Maribavir [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006464 SHP-620 VP 44469 Oxidation - N-dealkylation SHP-620 [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005533 VP 44469 Maribavir M1 Conjugation - Glucuronidation conjugation Maribavir [1]
References
1 Elucidation of Metabolic and Disposition Pathways for Maribavir in Nonhuman Primates through Mass Balance and Semi-Physiologically Based Modeling Approaches
2 Effect of ketoconazole on the pharmacokinetics of maribavir in healthy adults

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