Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR0743)
Drug Name
Fomepizole
Synonyms
Fomepizol; Fomepizol [INN-Spanish]; Fomepizole (Antizol); Fomepizole [USAN:INN:BAN]; Fomepizole [USAN:INN]; Fomepizole, 99%; Fomepizolum; Fomepizolum [INN-Latin]; PYRAZOLE, 4-METHYL-; RIKMMFOAQPJVMX-UHFFFAOYSA-N; fomepizole; zlchem 884; Antizol; Antizol (TN); Antizol-vet; 1H-Pyrazole, 4-methyl-; 4-Methyl-1H-pyrazole; 4-Methylpyrazol; 4-Methylpyrazole; 4-Methylpyrazole, 97%; 4-methyl pyrazole; 4-methyl-1h_pyrazole; 4-methyl-pyrazole; 7554-65-6; 83LCM6L2BY; BRN 0105204; C4H6N2; CHEBI:5141; EINECS 231-445-0; MFCD00005245; UNII-83LCM6L2BY
Indication Methanol/ethylene-glycol poisoning [ICD11: DA40] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 82.1 Topological Polar Surface Area 28.7
Heavy Atom Count 6 Rotatable Bond Count 0
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 1
Cross-matching ID
PubChem CID
3406
PubChem SID
10039 ; 3138709 ; 4792909 ; 7847772 ; 8152171 ; 10534897 ; 11111426 ; 12055784 ; 15170375 ; 24853343 ; 29222541 ; 31504178 ; 37464815 ; 39217062 ; 46508566 ; 48035242 ; 48442693 ; 49835006 ; 50029489 ; 50111124 ; 50139274 ; 53777054 ; 53788599 ; 57288740 ; 57321782 ; 57896964 ; 78011723 ; 81043498 ; 84974850 ; 85087794 ; 87572774 ; 90341211 ; 92721719 ; 99451186 ; 99495445 ; 103406649 ; 104303422 ; 104814009 ; 117417629 ; 117417630 ; 124749944 ; 124880638 ; 125357243 ; 126582001 ; 126618912 ; 126649057 ; 126667121 ; 126738786 ; 127483523 ; 127983616
ChEBI ID
ChEBI:5141
CAS Number
7554-65-6
TTD Drug ID
D02NJA
Formula
C4H6N2
Canonical SMILES
CC1=CNN=C1
InChI
1S/C4H6N2/c1-4-2-5-6-3-4/h2-3H,1H3,(H,5,6)
InChIKey
RIKMMFOAQPJVMX-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
4-carboxypyrazole DM002053
3015937
Unclear 1 [3] , [2]
4-hydroxymethylpyrazole DM002054
3015210
Unclear 1 [4]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR001085 Fomepizole 4-carboxypyrazole Unclear CYP2E1 [3], [2]
MR001086 Fomepizole 4-hydroxymethylpyrazole Unclear Unclear [4]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 2E1 (CYP2E1) DME0013 Homo sapiens
CP2E1_HUMAN
1.14.14.1
[2]
References
1 Fomepizole was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 Treatment of patients with ethylene glycol or methanol poisoning: focus on fomepizole. Open Access Emerg Med. 2010 Aug 24;2:67-75.
3 Kinetics and metabolism of fomepizole in healthy humans Clin Toxicol (Phila). 2012 Jun;50(5):375-83. doi: 10.3109/15563650.2012.683197.
4 DrugBank(Pharmacology-Metabolism)Fomepizole

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