Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001086)
Formula
SVG example
Reactant Fomepizole Product 4-hydroxymethylpyrazole
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001085 Fomepizole 4-carboxypyrazole Unclear Fomepizole [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005975 GTPL-463 4-hydroxymethylpyrazole Unclear GTPL-463 [3]
MR003260 Propofol 4-hydroxymethylpyrazole Unclear Fospropofol [4]
MR003255 Propofol glucuronide 4-hydroxymethylpyrazole Oxidation - 4-Hydroxylation Fospropofol [5]
MR003254 4-Quinol sulfate 4-hydroxymethylpyrazole Conjugation - Glucuronidation Fospropofol [5]
References
1 Kinetics and metabolism of fomepizole in healthy humans Clin Toxicol (Phila). 2012 Jun;50(5):375-83. doi: 10.3109/15563650.2012.683197.
2 Treatment of patients with ethylene glycol or methanol poisoning: focus on fomepizole. Open Access Emerg Med. 2010 Aug 24;2:67-75.
3 DrugBank(Pharmacology-Metabolism):GTPL-463 Fomepizole
4 DrugBank(Pharmacology-Metabolism)Fospropofol
5 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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