Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR0968)
Drug Name
Lomefloxacin
Synonyms
Lomefloxacine; Lomefloxacine [French]; Lomefloxacino; Lomefloxacino [Spanish]; Lomefloxacinum; Lomefloxacinum [Latin]; SC 47111A; DM 10 (bactericide); SC-47111A; lomefloxacin; (+-)-1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; 1,4-Dihydro-6,8-difluoro-1-ethyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; 1-ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 98079-51-7; BRN 4210041; CCRIS 6305; CHEBI:116278; DM-10; LFLX
Indication Conjunctivitis [ICD11: 9A60] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 351.35 Topological Polar Surface Area 72.9
Heavy Atom Count 25 Rotatable Bond Count 3
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 8
Cross-matching ID
PubChem CID
3948
PubChem SID
9289 ; 602955 ; 5037068 ; 7849377 ; 7979788 ; 8152478 ; 11335540 ; 11360779 ; 11364325 ; 11366887 ; 11369449 ; 11372706 ; 11373775 ; 11377611 ; 11461751 ; 11466266 ; 11467386 ; 11484587 ; 11485972 ; 11488512 ; 11491309 ; 11491973 ; 11495245 ; 14851991 ; 24278514 ; 29223062 ; 46508499 ; 47291062 ; 47588922 ; 47588923 ; 47736397 ; 47736398 ; 48035031 ; 48110376 ; 48334411 ; 48334412 ; 49698401 ; 49835841 ; 50042514 ; 50111115 ; 50122921 ; 50122922 ; 50203310 ; 56313756 ; 57322062 ; 85321506 ; 85788434 ; 90340951 ; 92309292 ; 103178831
ChEBI ID
CHEBI:116278
CAS Number
98079-51-7
TTD Drug ID
D02KOF
Formula
C17H19F2N3O3
Canonical SMILES
CCN1C=C(C(=O)C2=CC(=C(C(=C21)F)N3CCNC(C3)C)F)C(=O)O
InChI
1S/C17H19F2N3O3/c1-3-21-8-11(17(24)25)16(23)10-6-12(18)15(13(19)14(10)21)22-5-4-20-9(2)7-22/h6,8-9,20H,3-5,7H2,1-2H3,(H,24,25)
InChIKey
ZEKZLJVOYLTDKK-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
N-Desmethylamifloxacin DM006412
145907
Oxidation - N-demethylation 1 [2]
Lomefloxacin glucuronide metabolite DM006413 N. A. Conjugation - Glucuronidation 2 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR006891 Lomefloxacin N-Desmethylamifloxacin Oxidation - N-demethylation CYP1A2 [2]
MR006892 N-Desmethylamifloxacin Lomefloxacin glucuronide metabolite Conjugation - Glucuronidation UGT [3]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 1A2 (CYP1A2) DME0003 Homo sapiens
CP1A2_HUMAN
1.14.14.1
[2]
References
1 Lomefloxacin was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 Inhibitory potency of quinolone antibacterial agents against cytochrome P450IA2 activity in vivo and in vitro. Antimicrob Agents Chemother. 1992 May;36(5):942-8.
3 Pubchem:Lomefloxacin

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