Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR1050)
Drug Name
Methsuximide
Synonyms
Mesuximida; Mesuximida [INN-Spanish]; Mesuximide; Mesuximidum; Mesuximidum [INN-Latin]; Methsuximid; Metosuccimmide [DCIT]; Metsuccimide; N,2-Dimethyl-2-phenylsuccinimide; PM 396; Petinutin; alpha-Methylphensuximide; Celontin; METHSUXIMIDE; mesuximid; 1,3-Dimethyl-3-phenyl-2,5-dioxopyrrolidine; 1,3-Dimethyl-3-phenyl-2,5-pyrrolidinedione; 1,3-Dimethyl-3-phenyl-pyrrolidin-2,5-dione; 1,3-Dimethyl-3-phenylsuccinimide; 1,3-dimethyl-3-phenylpyrrolidine-2,5-dione; 2,5-Pyrrolidinedione, 1,3-dimethyl-3-phenyl-; 77-41-8
Indication Epilepsy [ICD11: 8A60] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 203.24 Topological Polar Surface Area 37.4
Heavy Atom Count 15 Rotatable Bond Count 1
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 2
Cross-matching ID
PubChem CID
6476
PubChem SID
7784245 ; 7847470 ; 7979936 ; 8154134 ; 10535562 ; 15171756 ; 29225451 ; 46505339 ; 48416252 ; 50048511 ; 57323472 ; 80615582 ; 92714623 ; 103193143 ; 104312168 ; 117476298 ; 121362356 ; 124899410 ; 126408324 ; 126629476 ; 126678061 ; 127417438 ; 134221929 ; 134338490 ; 134972484 ; 140288923 ; 144076268 ; 144207162 ; 144224652 ; 152101592 ; 160967839 ; 163118037 ; 164762136 ; 164762137 ; 175611120 ; 177513111 ; 178103802 ; 179225910 ; 204425454 ; 223366887 ; 223681174 ; 226421231 ; 241142344 ; 249582230 ; 249991606
ChEBI ID
CHEBI:6846
CAS Number
77-41-8
TTD Drug ID
D08EOD
Formula
C12H13NO2
Canonical SMILES
CC1(CC(=O)N(C1=O)C)C2=CC=CC=C2
InChI
1S/C12H13NO2/c1-12(9-6-4-3-5-7-9)8-10(14)13(2)11(12)15/h3-7H,8H2,1-2H3
InChIKey
AJXPJJZHWIXJCJ-UHFFFAOYSA-N
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Mephenytoin 4-hydroxylase (CYP2C19) DME0021 Homo sapiens
CP2CJ_HUMAN
1.14.14.1
[2]
Unclear metabolic mechanism (DME-unclear) DME1365 Bacteroides dorei Not Available Not Available [3]
Unclear metabolic mechanism (DME-unclear) DME1402 Clostridium botulinum Not Available Not Available [3]
References
1 Methsuximide was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 The role of S-mephenytoin hydroxylase (CYP2C19) in the metabolism of the antimalarial biguanides. Br J Clin Pharmacol. 1995 Apr;39(4):441-4.
3 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.