Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR3525)
Drug Name
FARGLITAZAR
Synonyms
Farglitazar; GI-262570; GI262570; 196808-45-4; GI 262570; UNII-3433GY7132; CHEMBL107367; GI-262570X; 2-(2-BENZOYL-PHENYLAMINO)-3-{4-[2-(5-METHYL-2-PHENYL-OXAZOL-4-YL)-ETHOXY]-PHENYL}-PROPIONIC ACID; 3433GY7132; L-Tyrosine, N-(2-benzoylphenyl)-o-(2-(5-methyl-2-phenyl-4-oxazolyl)ethyl)-; L-Tyrosine, N-(2-benzoylphenyl)-o-(2-(5-methyl-2-phenyl-4-oxazolyl)ethyl); N-(o-Benzoylphenyl)-O-(2-(5-methyl-2-phenyl-4-oxazolyl)ethyl)-L-tyrosine; Farglitazar [USAN]; Farglitazar [USAN:INN]; L-tyrosine, N-(2-benzoylphenyl)-O-[2-(5-methyl-
Indication Diabetes mellitus [ICD11: 5A10] Phase 3 [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 546.6 Topological Polar Surface Area 102
Heavy Atom Count 41 Rotatable Bond Count 12
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 7
Cross-matching ID
PubChem CID
170364
CAS Number
196808-45-4
TTD Drug ID
D0M0SS
Formula
C34H30N2O5
Canonical SMILES
CC1=C(N=C(O1)C2=CC=CC=C2)CCOC3=CC=C(C=C3)C[C@@H](C(=O)O)NC4=CC=CC=C4C(=O)C5=CC=CC=C5
InChI
InChI=1S/C34H30N2O5/c1-23-29(36-33(41-23)26-12-6-3-7-13-26)20-21-40-27-18-16-24(17-19-27)22-31(34(38)39)35-30-15-9-8-14-28(30)32(37)25-10-4-2-5-11-25/h2-19,31,35H,20-22H2,1H3,(H,38,39)/t31-/m0/s1
InChIKey
ZZCHHVUQYRMYLW-HKBQPEDESA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
2-aminobenzopjenone DM015074
76080
Oxidation - Oxidation 1 [2]
Decarboxylation product DM005727
71156779
Other reaction - Light 1 [2]
Farglitazar Metabolites M11 DM019457 N. A. Oxidation - Oxidation 1 [2]
Farglitazar Metabolites M12 DM019458 N. A. Oxidation - Oxidation 1 [2]
Triamide DM019455 N. A. Unclear - Unclear 1 [2]
Farglitazar Metabolites M3 DM019456 N. A. Hydrolysis - Hydrolysis 2 [2]
Farglitazar Metabolites M5 DM015580
9968894
Unclear - Unclear 2 [2]
Farglitazar Metabolites M7 DM016010
22568300
Unclear - Unclear 2 [2]
Midostaurin Metabolite P6 DM001360
243
Unclear - Unclear 2 [2]
Benzamide DM006921
2331
Hydrolysis - Hydrolysis 3 [2]
Diacid DM014901
6488
Hydrolysis - Hydrolysis 3 [2]
Midostaurin Metabolite P6 DM001360
243
Hydrolysis - Hydrolysis 3 [2]
Midostaurin Metabolite P6 DM001360
243
Hydrolysis - Hydrolysis 4 [2]
⏷ Show the Full List of 13  DM(s)
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR012035 Farglitazar Triamide Unclear - Unclear Unclear [2]
MR012044 Farglitazar 2-aminobenzopjenone Oxidation - Oxidation Unclear [2]
MR012045 Farglitazar Farglitazar Metabolites M11 Oxidation - Oxidation Unclear [2]
MR012046 Farglitazar Farglitazar Metabolites M12 Oxidation - Oxidation Unclear [2]
MR012047 Farglitazar Decarboxylation product Other reaction - Light Unclear [2]
MR012036 Triamide Farglitazar Metabolites M3 Hydrolysis - Hydrolysis Unclear [2]
MR012041 Triamide Farglitazar Metabolites M5 Unclear - Unclear Unclear [2]
MR012042 Triamide Farglitazar Metabolites M7 Unclear - Unclear Unclear [2]
MR012043 Triamide Benzoic acid Unclear - Unclear Unclear [2]
MR012037 Farglitazar Metabolites M3 Benzamide Hydrolysis - Hydrolysis Unclear [2]
MR012039 Farglitazar Metabolites M3 Benzoic acid Hydrolysis - Hydrolysis Unclear [2]
MR012040 Farglitazar Metabolites M3 Diacid Hydrolysis - Hydrolysis Unclear [2]
MR012038 Benzamide Benzoic acid Hydrolysis - Hydrolysis Unclear [2]
⏷ Show the Full List of 13 MR(s)
References
1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2672).
2 The Degradation Chemistry of Farglitazar and Elucidation of the Oxidative Degradation Mechanisms

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