Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012039)
Formula
SVG example
Hydrolysis
Reactant Farglitazar Metabolites M3 Product Benzoic acid
Reactant Info Product Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012036 Triamide Farglitazar Metabolites M3 Hydrolysis - Hydrolysis Farglitazar [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012037 Farglitazar Metabolites M3 Benzamide Hydrolysis - Hydrolysis Farglitazar [1]
MR012040 Farglitazar Metabolites M3 Diacid Hydrolysis - Hydrolysis Farglitazar [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005729 Benzyl alcohol Benzoic Acid Oxidation - Oxidationn Benzyl alcohol [2], [3]
MR007541 Benzylamine Benzylamine M16 Unclear Benzylamine [4]
MR004753 Midostaurin Midostaurin Metabolite P6 Unclear Midostaurin [5]
MR004299 Naphthoquinone Benzoic acid Unclear Naphthoquinone [6]
MR000218 Phenylacetone Benzoic acid Oxidation - Oxidation Amphetamine [7]
MR012043 Triamide Benzoic acid Unclear - Unclear Farglitazar [1]
MR003835 3-Phenylpropionic acid Benzoic acid Unclear BE-14348A [8]
MR009986 Metamfetamine Metabolite M5 Benzoic acid Unclear - Unclear Metamfetamine [9]
MR010002 Metamfetamine Metabolite M5 Benzoic acid Unclear - Unclear Methamphetamine hydrochloride [9]
MR012038 Benzamide Benzoic acid Hydrolysis - Hydrolysis Farglitazar [1]
MR006884 Phenylacetone Benzoic Acid Unclear Lisdexamfetamine [10]
MR009198 3-(phenyl)acetic acid Benzoic acid Oxidation - Oxidation 3,4-Dihydroxycinnamic Acid [11]
MR005288 Cinnamic acid Metabolite Benzoic acid Unclear Cinnamic acid [12]
MR004493 3-Hydroxybenzoic acid Benzoic acid Unclear VS-12343 [13]
MR004491 Phenylacetic acid Benzoic acid Unclear VS-12343 [13]
⏷ Show the Full List of MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007547 Benzylamine M16 Benzylamine M1 Unclear Benzylamine [4]
MR007542 Benzylamine M16 Benzylamine M12 Unclear Benzylamine [4]
MR004754 Midostaurin Metabolite P6 Midostaurin Metabolite P6B Unclear Midostaurin [5]
References
1 The Degradation Chemistry of Farglitazar and Elucidation of the Oxidative Degradation Mechanisms
2 Effects of ALDH2, CYP1A1, and CYP2E1 genetic polymorphisms and smoking and drinking habits on toluene metabolism in humans. Toxicol Appl Pharmacol. 1995 Aug;133(2):295-304.
3 Final report on the safety assessment of Benzyl Alcohol, Benzoic Acid, and Sodium Benzoate
4 Bioactivation of benzylamine to reactive intermediates in rodents: formation of glutathione, glutamate, and peptide conjugates
5 Midostaurin, a novel protein kinase inhibitor for the treatment of acute myelogenous leukemia: insights from human absorption, metabolism, and excretion studies of a BDDCS II drug. Drug Metab Dispos. 2017 May;45(5):540-555.
6 Identification of naphthalene metabolism by white rot fungus Pleurotus eryngii
7 DrugBank(Pharmacology-Metabolism)Amphetamine
8 High gastrointestinal permeability and local metabolism of naringenin: influence of antibiotic treatment on absorption and metabolism
9 Metabolism of ( 14 C)methamphetamine in man, the guinea pig and the rat
10 Preclinical pharmacokinetics, pharmacology and toxicology of lisdexamfetamine: a novel d-amphetamine pro-drug. Neuropharmacology. 2014 Dec;87:41-50.
11 In vitro catabolism of 3',4'-dihydroxycinnamic acid by human colonic microbiota
12 Metabolism of trans-cinnamic acid in the rat and the mouse and its variation with dose
13 Biotransformation of two citrus flavanones by lactic acid bacteria in chemical defined medium

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