Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000007)
Formula
SVG example
Hydroxylation
Reactant N-desethylabemaciclib Product Hydroxy-N-desethylabemaciclib
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000009 Abemaciclib N-desethylabemaciclib Oxidation - N-Dealkylation Abemaciclib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000008 Hydroxyabemaciclib Hydroxy-N-desethylabemaciclib Oxidation - N-Dealkylation Abemaciclib [1]
References
1 Simultaneous quantification of abemaciclib and its active metabolites in human and mouse plasma by UHPLC-MS/MS J Pharm Biomed Anal. 2021 Sep 5;203:114225. doi: 10.1016/j.jpba.2021.114225.

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