Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000008)
Formula
SVG example
N-Dealkylation
Reactant Hydroxyabemaciclib Product Hydroxy-N-desethylabemaciclib
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000010 Abemaciclib Hydroxyabemaciclib Oxidation - Hydroxylation Abemaciclib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000007 N-desethylabemaciclib Hydroxy-N-desethylabemaciclib Oxidation - Hydroxylation Abemaciclib [1]
References
1 Simultaneous quantification of abemaciclib and its active metabolites in human and mouse plasma by UHPLC-MS/MS J Pharm Biomed Anal. 2021 Sep 5;203:114225. doi: 10.1016/j.jpba.2021.114225.

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