Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000011)
Formula
SVG example
Hydroxyl Sulphation
Reactant Abiraterone Product Abiraterone sulfate
Reactant Info Product Info
Metabolic Enzyme Sulfotransferase 2A1 (SULT2A1) DME Info
Metabolic Type Conjugation - Hydroxyl Sulphation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010805 ABIRATERONE 3-keto-Delta4-Abiraterone(D4A) Unclear - Unclear ABIRATERONE [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000012 Abiraterone sulfate N-oxide abiraterone sulfate Oxidation - Oxidation Abiraterone acetate [2]
References
1 The interactions of a number of steroid-metabolizing cytochromes P450 with abiraterone D4A metabolite: spectral analysis and molecular docking
2 Conversion of abiraterone to D4A drives anti-tumour activity in prostate cancer Nature. 2015 Jul 16;523(7560):347-51. doi: 10.1038/nature14406.

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