Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010805)
Formula
SVG example
Unclear
Reactant ABIRATERONE Product 3-keto-Delta4-Abiraterone(D4A)
Reactant Info Product Info
Metabolic Enzyme 3 beta-hydroxysteroid dehydrogenase (HSD3B) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000011 Abiraterone Abiraterone sulfate Conjugation - Hydroxyl Sulphation Abiraterone acetate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000014 Abiraterone acetate D4A Oxidation - Dehydrogenation Abiraterone acetate [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010806 3-keto-Delta4-Abiraterone(D4A) 3-keto-5alpha-Abiraterone Unclear - Unclear ABIRATERONE [3]
MR010807 3-keto-Delta4-Abiraterone(D4A) 3-keto-5beta-Abiraterone Unclear - Unclear ABIRATERONE [3]
References
1 Abiraterone for the treatment of metastatic castrate-resistant prostate cancer. Ann Pharmacother. 2012 Jul-Aug;46(7-8):1016-24.
2 Conversion of abiraterone to D4A drives anti-tumour activity in prostate cancer Nature. 2015 Jul 16;523(7560):347-51. doi: 10.1038/nature14406.
3 The interactions of a number of steroid-metabolizing cytochromes P450 with abiraterone D4A metabolite: spectral analysis and molecular docking

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