Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000029)
Formula
SVG example
Reactant Acecainide Product N-acetyl-3-hydroxyprocainamide
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000032 Acecainide Desethyl-N-acetylprocainamide Oxidation - Desethylation Acecainide [1]
MR000033 Acecainide N-acetyl-4-aminobenzoic acid Unclear Acecainide [1]
MR000031 Acecainide N-acetyl-4-aminohippuric acid Unclear Acecainide [1]
MR000030 Acecainide N-acetylprocainamide-N-oxide Unclear Acecainide [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002156 Procainamide hydrochloride N-Acetyl-3-hydroxyprocainamide Oxidation - N-Hydroxylation Procainamide hydrochloride [2], [3]
References
1 The implications of procainamide metabolism to its induction of lupus Arthritis Rheum. 1981 Aug;24(8):994-1003. doi: 10.1002/art.1780240803.
2 Involvement of CYP2D6 activity in the N-oxidation of procainamide in man. Pharmacogenetics. 1999 Dec;9(6):683-96.
3 Metabolites of procainamide and practolol inhibit complement components C3 and C4 Biochem J. 1988 Apr 15;251(2):323-6. doi: 10.1042/bj2510323.

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