Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002156)
Formula
SVG example
N-Hydroxylation
Reactant Procainamide hydrochloride Product N-Acetyl-3-hydroxyprocainamide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - N-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002157 Procainamide hydrochloride Desethylprocainamide Oxidation - Deethylation Procainamide hydrochloride [1]
MR002158 Procainamide hydrochloride Procainamide 4-hydroxylamine Oxidation - Hydroxylation Procainamide hydrochloride [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000029 Acecainide N-acetyl-3-hydroxyprocainamide Unclear Acecainide [2]
References
1 Metabolites of procainamide and practolol inhibit complement components C3 and C4 Biochem J. 1988 Apr 15;251(2):323-6. doi: 10.1042/bj2510323.
2 The implications of procainamide metabolism to its induction of lupus Arthritis Rheum. 1981 Aug;24(8):994-1003. doi: 10.1002/art.1780240803.

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