General Information of This Metabolic Reaction (MR) (ID: MR000048)
Formula
UGT2B15 ...
SVG example
Glucuronidation
Reactant Acetaminophen Product Acetaminophen glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 2B15 (UGT2B15) DME Info
UDP-glucuronosyltransferase 1A10 (UGT1A10) DME Info
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
UDP-glucuronosyltransferase 1A6 (UGT1A6) DME Info
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000049 Acetaminophen Acetaminophen sulfate Conjugation - Sulfation Acetaminophen [1], [2], [3]
MR000050 Acetaminophen NAPQI Oxidation - Oxidation Acetaminophen [4], [5]
MR002013 Acetaminophen Acetaminophen sulfate Unclear Phenacetin [6]
MR002014 Acetaminophen NAPQI Oxidation - Oxidation Phenacetin [6]
References
1 Simultaneous quantification of abemaciclib and its active metabolites in human and mouse plasma by UHPLC-MS/MS J Pharm Biomed Anal. 2021 Sep 5;203:114225. doi: 10.1016/j.jpba.2021.114225.
2 Application of a Volumetric Absorptive Microsampling (VAMS)-Based Method for the Determination of Paracetamol and Four of its Metabolites as a Tool for Pharmacokinetic Studies in Obese and Non-Obese Patients. Clin Pharmacokinet. 2022 Dec;61(12):1719-1733. doi: 10.1007/s40262-022-01187-2.
3 Evaluation of urinary acetaminophen metabolites and its association with the genetic polymorphisms of the metabolising enzymes, and serum acetaminophen concentrations in preterm neonates with patent ductus arteriosus. Xenobiotica. 2021 Nov;51(11):1335-1342. doi: 10.1080/00498254.2021.1982070.
4 Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents FASEB J. 2010 Dec;24(12):4904-16. doi: 10.1096/fj.10-162438.
5 Rapid detection and quantification of paracetamol and its major metabolites using surface enhanced Raman scattering. Analyst. 2023 Apr 11;148(8):1805-1814. doi: 10.1039/d3an00249g.
6 DrugBank(Pharmacology-Metabolism)Phenacetin

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