General Information of This Metabolic Reaction (MR) (ID: MR002013)
Formula
CYP1A1 ...
SVG example
Reactant Acetaminophen Product Acetaminophen sulfate
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A1 (CYP1A1) DME Info
Sulfotransferase 1A3 (SULT1A3) DME Info
Sulfotransferase 1A1 (SULT1A1) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000048 Acetaminophen Acetaminophen glucuronide Conjugation - Glucuronidation Acetaminophen [1], [2], [3]
MR000050 Acetaminophen NAPQI Oxidation - Oxidation Acetaminophen [4], [5]
MR002012 Acetaminophen Acetaminophen glucuronide Conjugation - Glucuronidation Phenacetin [6]
MR002014 Acetaminophen NAPQI Oxidation - Oxidation Phenacetin [6]
References
1 Simultaneous quantification of abemaciclib and its active metabolites in human and mouse plasma by UHPLC-MS/MS J Pharm Biomed Anal. 2021 Sep 5;203:114225. doi: 10.1016/j.jpba.2021.114225.
2 Application of a Volumetric Absorptive Microsampling (VAMS)-Based Method for the Determination of Paracetamol and Four of its Metabolites as a Tool for Pharmacokinetic Studies in Obese and Non-Obese Patients. Clin Pharmacokinet. 2022 Dec;61(12):1719-1733. doi: 10.1007/s40262-022-01187-2.
3 Evaluation of urinary acetaminophen metabolites and its association with the genetic polymorphisms of the metabolising enzymes, and serum acetaminophen concentrations in preterm neonates with patent ductus arteriosus. Xenobiotica. 2021 Nov;51(11):1335-1342. doi: 10.1080/00498254.2021.1982070.
4 Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents FASEB J. 2010 Dec;24(12):4904-16. doi: 10.1096/fj.10-162438.
5 Rapid detection and quantification of paracetamol and its major metabolites using surface enhanced Raman scattering. Analyst. 2023 Apr 11;148(8):1805-1814. doi: 10.1039/d3an00249g.
6 DrugBank(Pharmacology-Metabolism)Phenacetin

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