Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000114)
Formula
SVG example
Reactant 1,25-dihydroxyvitamin D3 Product 1,25-dihydroxyvitamin D3-26,23-lactone
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000118 Alfacalcidol 1,25-dihydroxyvitamin D3 Unclear Alfacalcidol [1]
MR002812 Calcifediol Calcitriol Oxidation - 25-Hydroxylation Calcifediol [2]
MR006671 Doxercalciferol 1alpha,25-dihydroxyvitamin D? Unclear Doxercalciferol [3], [4]
MR010846 Calcidiol Calcitriol Unclear - Unclear Cholecalciferol [5]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000117 1,25-dihydroxyvitamin D3 1,24,25-trihydroxyvitamin D3 Unclear Alfacalcidol [6]
MR000115 1,25-dihydroxyvitamin D3 1,25,26-trihydroxyvitamin D3 Unclear Alfacalcidol [6]
MR000116 1,25-dihydroxyvitamin D3 24-oxo-1,25-dihydroxyvitamin D3 Unclear Alfacalcidol [6]
MR000113 1,25-dihydroxyvitamin D3 Calcitroic Acid Unclear Alfacalcidol [6]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002816 Calcitriol 1a,25R(OH)2-26,23S-lactone D3 Oxidation - Hydroxylation Calcitriol [7], [2]
MR002814 Calcitriol 1a,25R(OH)2-26,23S-lactone D3 Oxidation - Hydroxylation Calcifediol [2]
References
1 A new look at the most successful prodrugs for active vitamin D (D hormone): alfacalcidol and doxercalciferol Molecules. 2009 Sep 29;14(10):3869-80. doi: 10.3390/molecules14103869.
2 Cytochromes P450 are essential players in the vitamin D signaling system. Biochim Biophys Acta. 2011 Jan;1814(1):186-99.
3 Comparative effects of doxercalciferol (1-hydroxyvitamin D?) versus calcitriol (1,25-dihydroxyvitamin D?) on the expression of transporters and enzymes in the rat in vivo
4 Pharmacokinetics of doxercalciferol, a new vitamin D analogue that lowers parathyroid hormone
5 Vitamin D Metabolite Profile in Cholecalciferol- or Calcitriol-Supplemented Healthy and Mammary Gland Tumor-Bearing Mice
6 Metabolism of 1,25-dihydroxyvitamin D3 Physiol Rev. 1984 Apr;64(2):478-504. doi: 10.1152/physrev.1984.64.2.478.
7 Intestinal and hepatic CYP3A4 catalyze hydroxylation of 1alpha,25-dihydroxyvitamin D(3): implications for drug-induced osteomalacia. Mol Pharmacol. 2006 Jan;69(1):56-65.

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