Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006671)
Formula
SVG example
Reactant Doxercalciferol Product 1alpha,25-dihydroxyvitamin D?
Reactant Info Product Info
Metabolic Enzyme Vitamin D 25-hydroxylase (CYP2R1) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006672 Doxercalciferol 1alpha,24-dihydroxyvitamin D2 Unclear Doxercalciferol [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000118 Alfacalcidol 1,25-dihydroxyvitamin D3 Unclear Alfacalcidol [2]
MR002812 Calcifediol Calcitriol Oxidation - 25-Hydroxylation Calcifediol [3]
MR010846 Calcidiol Calcitriol Unclear - Unclear Cholecalciferol [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000117 1,25-dihydroxyvitamin D3 1,24,25-trihydroxyvitamin D3 Unclear Alfacalcidol [5]
MR000115 1,25-dihydroxyvitamin D3 1,25,26-trihydroxyvitamin D3 Unclear Alfacalcidol [5]
MR000114 1,25-dihydroxyvitamin D3 1,25-dihydroxyvitamin D3-26,23-lactone Unclear Alfacalcidol [2]
MR000116 1,25-dihydroxyvitamin D3 24-oxo-1,25-dihydroxyvitamin D3 Unclear Alfacalcidol [5]
MR000113 1,25-dihydroxyvitamin D3 Calcitroic Acid Unclear Alfacalcidol [5]
References
1 DrugBank(Pharmacology-Metabolism):Doxercalciferol
2 A new look at the most successful prodrugs for active vitamin D (D hormone): alfacalcidol and doxercalciferol Molecules. 2009 Sep 29;14(10):3869-80. doi: 10.3390/molecules14103869.
3 Cytochromes P450 are essential players in the vitamin D signaling system. Biochim Biophys Acta. 2011 Jan;1814(1):186-99.
4 Vitamin D Metabolite Profile in Cholecalciferol- or Calcitriol-Supplemented Healthy and Mammary Gland Tumor-Bearing Mice
5 Metabolism of 1,25-dihydroxyvitamin D3 Physiol Rev. 1984 Apr;64(2):478-504. doi: 10.1152/physrev.1984.64.2.478.

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