Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000123)
Formula
CYP
SVG example
Oxidation
Reactant Alfentanil Product Alfentanil metabolite AM5
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 (CYP) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000125 Alfentanil 2-(4-ethyl-5-oxo-1,2,3,4-tetrazol-1-yl)acetaldehyde Oxidation - N-Dealkylation Alfentanil [1]
MR000126 Alfentanil Alfentanil metabolite AM14 Oxidation - O-Demethylation Alfentanil [1]
MR000124 Alfentanil N-phenylpropionamide Oxidation - O-Demethylation Alfentanil [2]
MR000122 Alfentanil Noralfentanil Oxidation - N-Dealkylation Alfentanil [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000120 Noralfentanil Alfentanil metabolite AM5 Oxidation - Oxidation Alfentanil [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000121 Alfentanil metabolite AM5 Alfentanil metabolite AM3 Hydrolysis - Amid Hydrolysis; Acetylation Alfentanil [1]
References
1 Alfentanil pharmacokinetics and metabolism in humans Anesthesiology. 1988 Oct;69(4):527-34. doi: 10.1097/00000542-198810000-00012.
2 Metabolism of alfentanil by cytochrome p4503a (cyp3a) enzymes. Drug Metab Dispos. 2005 Mar;33(3):303-11.

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