Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000122)
Formula
CYP3A4 ...
SVG example
N-Dealkylation
Reactant Alfentanil Product Noralfentanil
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - N-Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000125 Alfentanil 2-(4-ethyl-5-oxo-1,2,3,4-tetrazol-1-yl)acetaldehyde Oxidation - N-Dealkylation Alfentanil [1]
MR000126 Alfentanil Alfentanil metabolite AM14 Oxidation - O-Demethylation Alfentanil [1]
MR000123 Alfentanil Alfentanil metabolite AM5 Oxidation - Oxidation Alfentanil [1]
MR000124 Alfentanil N-phenylpropionamide Oxidation - O-Demethylation Alfentanil [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000120 Noralfentanil Alfentanil metabolite AM5 Oxidation - Oxidation Alfentanil [1]
MR000119 Noralfentanil Alfentanil metabolite AM6 Oxidation - O-Demethylation Alfentanil [1]
References
1 Alfentanil pharmacokinetics and metabolism in humans Anesthesiology. 1988 Oct;69(4):527-34. doi: 10.1097/00000542-198810000-00012.
2 Metabolism of alfentanil by cytochrome p4503a (cyp3a) enzymes. Drug Metab Dispos. 2005 Mar;33(3):303-11.

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