Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000247)
Formula Reactant Apixaban M4/7 metabolite Product Apixaban M13 metabolite
Reactant Info Product Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000249 Apixaban Apixaban M4/7 metabolite Oxidation - Hydroxylation Apixaban [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000244 Apixaban M2 metabolite Apixaban M13 metabolite Oxidation - Hydroxylation Apixaban [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000246 Apixaban M13 metabolite Apixaban M10 metabolite Conjugation - Sulfation Apixaban [3]
References
1 Apixaban. Hosp Pharm. 2013 Jun;48(6):494-509.
2 Apixaban. After hip or knee replacement: LMWH remains the standard treatment. Prescrire Int. 2012 Sep;21(130):201-2, 204.
3 Apixaban metabolism and pharmacokinetics after oral administration to humans Drug Metab Dispos. 2009 Jan;37(1):74-81. doi: 10.1124/dmd.108.023143.

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