Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000249)
Formula Reactant Apixaban Product Apixaban M4/7 metabolite
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2J2 (CYP2J2) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000248 Apixaban Apixaban M2 metabolite Oxidation - O-Demethylation Apixaban [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000247 Apixaban M4/7 metabolite Apixaban M13 metabolite Oxidation - Hydroxylation Apixaban [3]
References
1 Apixaban. Hosp Pharm. 2013 Jun;48(6):494-509.
2 Apixaban. After hip or knee replacement: LMWH remains the standard treatment. Prescrire Int. 2012 Sep;21(130):201-2, 204.
3 Apixaban metabolism and pharmacokinetics after oral administration to humans Drug Metab Dispos. 2009 Jan;37(1):74-81. doi: 10.1124/dmd.108.023143.

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