Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM000615)
DM Name	Apixaban M4/7 metabolite

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 1A2 (CYP1A2)	DME0003	Apixaban	Oxidation - Hydroxylation	Apixaban	[1] , [2]
Cytochrome P450 2C8 (CYP2C8)	DME0018	Apixaban	Oxidation - Hydroxylation	Apixaban	[1] , [2]
Cytochrome P450 2C9 (CYP2C9)	DME0019	Apixaban	Oxidation - Hydroxylation	Apixaban	[1] , [2]
Cytochrome P450 2J2 (CYP2J2)	DME0031	Apixaban	Oxidation - Hydroxylation	Apixaban	[1] , [2]
Cytochrome P450 3A4 (CYP3A4)	DME0001	Apixaban	Oxidation - Hydroxylation	Apixaban	[1] , [2]
Cytochrome P450 3A5 (CYP3A5)	DME0012	Apixaban	Oxidation - Hydroxylation	Apixaban	[1] , [2]
Mephenytoin 4-hydroxylase (CYP2C19)	DME0021	Apixaban	Oxidation - Hydroxylation	Apixaban	[1] , [2]

Full List of Drug(s) That Produce This DM By Metabolism
Apixaban		DR0122	Approved		Deep vein thrombosis

References
1	Apixaban. Hosp Pharm. 2013 Jun;48(6):494-509.
2	Apixaban. After hip or knee replacement: LMWH remains the standard treatment. Prescrire Int. 2012 Sep;21(130):201-2, 204.

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