Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000290)
Formula
CYP3A4 ...
SVG example
Dehydrogenation
Reactant Aripiprazole Product Dehydro-aripiprazole
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - Dehydrogenation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000288 N-hydroxymethyl-aripiprazole Aripiprazole Hydrolysis - Hydrolysis Aripiprazole lauroxil [1], [2]
References
1 Aripiprazole Lauroxil: Pharmacokinetic Profile of This Long-Acting Injectable Antipsychotic in Persons With Schizophrenia J Clin Psychopharmacol. 2017 Jun;37(3):289-295. doi: 10.1097/JCP.0000000000000691.
2 Biological conversion of?aripiprazole lauroxil - An N-acyloxymethyl aripiprazole prodrug Results Pharma Sci. 2014 May 2;4:19-25. doi: 10.1016/j.rinphs.2014.04.002.

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