Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000296)
Formula
SVG example
Methylation
Reactant Arsenic Product Monomethylarsonic acid
Reactant Info Product Info
Metabolic Enzyme Arsenite methyltransferase (AS3MT) DME Info
Metabolic Type Conjugation - Methylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000297 Arsenic Dimethylarsinic acid Conjugation - Methylation Arsenic [1], [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012722 Arsenous acid (AsIII) Monomethylarsonic acid(MMAV) Conjugation - O-methylation Arsenic trioxide [4], [5], [6]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000295 Monomethylarsonic acid Dimethylarsinic acid Conjugation - Methylation Arsenic [7], [2]
MR012723 Monomethylarsonic acid(MMAV) Dimethylarsinic acid (DMAV) Conjugation - O-methylation Arsenic trioxide [4], [5], [6]
References
1 Polymorphisms in arsenic(+III oxidation state) methyltransferase (AS3MT) predict gene expression of AS3MT as well as arsenic metabolism. Environ Health Perspect. 2011 Feb;119(2):182-8.
2 Prenatal arsenic exposure, arsenic metabolism and neurocognitive development of 2-year-old children in low-arsenic areas. Environ Int. 2023 Apr;174:107918. doi: 10.1016/j.envint.2023.107918.
3 Arsenic metabolism, N6AMT1 and AS3MT single nucleotide polymorphisms, and their interaction on gestational diabetes mellitus in Chinese pregnant women. Environ Res. 2023 Mar 15;221:115331. doi: 10.1016/j.envres.2023.115331.
4 Type 2 diabetes affects arsenic metabolism via transporters in arsenic trioxide treated acute promyelocytic leukemia patients
5 Biotransformation of arsenic trioxide by AS3MT favors eradication of acute promyelocytic leukemia: revealing the hidden facts
6 LABEL:ARSENIC TRIOXIDE injection
7 Interactive influence of N6AMT1 and As3MT genetic variations on arsenic metabolism in the population of Inner Mongolia, China. Toxicol Sci. 2017 Jan;155(1):124-134.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.