Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012723)
Formula
SVG example
O-methylation
Reactant Monomethylarsonic acid(MMAV) Product Dimethylarsinic acid (DMAV)
Reactant Info Product Info
Metabolic Enzyme Arsenite methyltransferase (AS3MT) DME Info
Metabolic Type Conjugation - O-methylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000296 Arsenic Monomethylarsonic acid Conjugation - Methylation Arsenic [1], [2], [3]
MR012722 Arsenous acid (AsIII) Monomethylarsonic acid(MMAV) Conjugation - O-methylation Arsenic trioxide [4], [5], [6]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000297 Arsenic Dimethylarsinic acid Conjugation - Methylation Arsenic [1], [2], [3]
References
1 Polymorphisms in arsenic(+III oxidation state) methyltransferase (AS3MT) predict gene expression of AS3MT as well as arsenic metabolism. Environ Health Perspect. 2011 Feb;119(2):182-8.
2 Prenatal arsenic exposure, arsenic metabolism and neurocognitive development of 2-year-old children in low-arsenic areas. Environ Int. 2023 Apr;174:107918. doi: 10.1016/j.envint.2023.107918.
3 Arsenic metabolism, N6AMT1 and AS3MT single nucleotide polymorphisms, and their interaction on gestational diabetes mellitus in Chinese pregnant women. Environ Res. 2023 Mar 15;221:115331. doi: 10.1016/j.envres.2023.115331.
4 Type 2 diabetes affects arsenic metabolism via transporters in arsenic trioxide treated acute promyelocytic leukemia patients
5 Biotransformation of arsenic trioxide by AS3MT favors eradication of acute promyelocytic leukemia: revealing the hidden facts
6 LABEL:ARSENIC TRIOXIDE injection

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