Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012722)
Formula Reactant Arsenous acid (AsIII) Product Monomethylarsonic acid(MMAV)
Reactant Info Product Info
Metabolic Enzyme Arsenite methyltransferase (AS3MT) DME Info
Metabolic Type Conjugation - O-methylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012721 Arsenic trioxide Arsenous acid (AsIII) Hydrolysis - Hydrolysis Arsenic trioxide [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012724 Arsenous acid (AsIII) Arsenic acid (AsV) Conjugation - O-methylation Arsenic trioxide [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000296 Arsenic Monomethylarsonic acid Conjugation - Methylation Arsenic [2], [3], [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000295 Monomethylarsonic acid Dimethylarsinic acid Conjugation - Methylation Arsenic [5], [3]
MR012723 Monomethylarsonic acid(MMAV) Dimethylarsinic acid (DMAV) Conjugation - O-methylation Arsenic trioxide [6], [7], [1]
References
1 LABEL:ARSENIC TRIOXIDE injection
2 Polymorphisms in arsenic(+III oxidation state) methyltransferase (AS3MT) predict gene expression of AS3MT as well as arsenic metabolism. Environ Health Perspect. 2011 Feb;119(2):182-8.
3 Prenatal arsenic exposure, arsenic metabolism and neurocognitive development of 2-year-old children in low-arsenic areas. Environ Int. 2023 Apr;174:107918. doi: 10.1016/j.envint.2023.107918.
4 Arsenic metabolism, N6AMT1 and AS3MT single nucleotide polymorphisms, and their interaction on gestational diabetes mellitus in Chinese pregnant women. Environ Res. 2023 Mar 15;221:115331. doi: 10.1016/j.envres.2023.115331.
5 Interactive influence of N6AMT1 and As3MT genetic variations on arsenic metabolism in the population of Inner Mongolia, China. Toxicol Sci. 2017 Jan;155(1):124-134.
6 Type 2 diabetes affects arsenic metabolism via transporters in arsenic trioxide treated acute promyelocytic leukemia patients
7 Biotransformation of arsenic trioxide by AS3MT favors eradication of acute promyelocytic leukemia: revealing the hidden facts

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