Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000331)
Formula
CYP2D6 ...
SVG example
Hydroxylation
Reactant Astemizole Product 6-hydroxyastemizole
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 3A43 (CYP3A43) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000332 Astemizole 2-(4-hydroxyphenyl)acetaldehyde Oxidation - N-Dealkylation Astemizole [1]
MR000333 Astemizole Desmethylastemizole Oxidation - O-Demethylation Astemizole [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000330 6-hydroxyastemizole 6-hydroxydesmethylastemizole Oxidation - O-Demethylation Astemizole [1]
References
1 Involvement of multiple human cytochromes P450 in the liver microsomal metabolism of astemizole and a comparison with terfenadine. Br J Clin Pharmacol. 2001 Feb;51(2):133-42.
2 DrugBank(Pharmacology-Metabolism)Astemizole

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