Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000333)
Formula
CYP2J2 ...
SVG example
O-Demethylation
Reactant Astemizole Product Desmethylastemizole
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2J2 (CYP2J2) DME Info
Cytochrome P450 3A43 (CYP3A43) DME Info
Metabolic Type Oxidation - O-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000332 Astemizole 2-(4-hydroxyphenyl)acetaldehyde Oxidation - N-Dealkylation Astemizole [1]
MR000331 Astemizole 6-hydroxyastemizole Oxidation - Hydroxylation Astemizole [1]
References
1 Involvement of multiple human cytochromes P450 in the liver microsomal metabolism of astemizole and a comparison with terfenadine. Br J Clin Pharmacol. 2001 Feb;51(2):133-42.

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