Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000337)
Formula Reactant AZD-2171 Product AZD-2171 metabolite M2
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 (CYP) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000336 AZD-2171 AZD-2171 metabolite M1 Oxidation - Dioxidation AZD-2171 [1]
MR000343 AZD-2171 AZD-2171 metabolite M11 Unclear AZD-2171 [1]
MR000338 AZD-2171 AZD-2171 metabolite M3 Conjugation - N-Glucuronidation AZD-2171 [1]
MR000339 AZD-2171 AZD-2171 metabolite M4 Oxidation - N-Oxidation AZD-2171 [1]
MR000340 AZD-2171 AZD-2171 metabolite M5 Unclear AZD-2171 [1]
MR000341 AZD-2171 AZD-2171 metabolite M7 Unclear AZD-2171 [1]
MR000342 AZD-2171 AZD-2171 metabolite M8 Unclear AZD-2171 [1]
References
1 In vitro hepatic metabolism of cediranib, a potent vascular endothelial growth factor tyrosine kinase inhibitor: interspecies comparison and human enzymology. Drug Metab Dispos. 2010 Oct;38(10):1688-97.

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