Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000338)
Formula
SVG example
N-Glucuronidation
Reactant AZD-2171 Product AZD-2171 metabolite M3
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A4 (UGT1A4) DME Info
Metabolic Type Conjugation - N-Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000336 AZD-2171 AZD-2171 metabolite M1 Oxidation - Dioxidation AZD-2171 [1]
MR000343 AZD-2171 AZD-2171 metabolite M11 Unclear AZD-2171 [1]
MR000337 AZD-2171 AZD-2171 metabolite M2 Unclear AZD-2171 [1]
MR000339 AZD-2171 AZD-2171 metabolite M4 Oxidation - N-Oxidation AZD-2171 [1]
MR000340 AZD-2171 AZD-2171 metabolite M5 Unclear AZD-2171 [1]
MR000341 AZD-2171 AZD-2171 metabolite M7 Unclear AZD-2171 [1]
MR000342 AZD-2171 AZD-2171 metabolite M8 Unclear AZD-2171 [1]
References
1 In vitro hepatic metabolism of cediranib, a potent vascular endothelial growth factor tyrosine kinase inhibitor: interspecies comparison and human enzymology. Drug Metab Dispos. 2010 Oct;38(10):1688-97.

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