Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000372)
Formula Reactant Binimetinib Product 1,4-Diiminoquinone intermediate
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Two-Electron Oxidation
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000366 1,4-Diiminoquinone intermediate GSH adduct Unclear Binimetinib [1]
References
1 Binimetinib Is a Potent Reversible and Time-Dependent Inhibitor of Cytochrome P450 1A2 Chem Res Toxicol. 2021 Apr 19;34(4):1169-1174. doi: 10.1021/acs.chemrestox.1c00036.

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