Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000417)
Formula
CYP3A4 ...
SVG example
Methyl-Hydroxylation
Reactant Bosentan Product Bosentan metabolite Ro 48-5033
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
DME Info
Metabolic Type Oxidation - Methyl-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000416 Bosentan Bosentan metabolite Ro 47-8634 Oxidation - O-Demethylation Bosentan [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000415 Bosentan metabolite Ro 48-5033 Bosentan metabolite Ro 64-1056 Oxidation - O-Demethylation Bosentan [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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