Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000445)
Formula Reactant Brigatinib Product BGB486
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000442 Brigatinib AP26123 Oxidation - N-Demethylation; Cysteine Conjugation Brigatinib [1]
MR000444 Brigatinib BGB570 Unclear Brigatinib [1]
MR000446 Brigatinib BGB598 Unclear Brigatinib [1]
MR000443 Brigatinib BGB600 Unclear Brigatinib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008513 AP26113 BGB486 Multi-steps Reaction - N-Dealkylation; loss of N-methyl piperazine ring AP26113 [2]
References
1 Brigatinib: first global approval. Drugs. 2017 Jul;77(10):1131-1135.
2 LC-ESI-MS/MS reveals the formation of reactive intermediates in brigatinib metabolism: elucidation of bioactivation pathways

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