Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000442)
Formula Reactant Brigatinib Product AP26123
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C8 (CYP2C8) DME Info
DME Info
Metabolic Type Oxidation - N-Demethylation; Cysteine Conjugation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000445 Brigatinib BGB486 Unclear Brigatinib [1]
MR000444 Brigatinib BGB570 Unclear Brigatinib [1]
MR000446 Brigatinib BGB598 Unclear Brigatinib [1]
MR000443 Brigatinib BGB600 Unclear Brigatinib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008510 AP26113 AP26123 Multi-steps Reaction - N-demethylation; cysteine conjugation AP26113 [1]
References
1 Brigatinib: first global approval. Drugs. 2017 Jul;77(10):1131-1135.

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