Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000461)
Formula Reactant Bromfenac Product Bromfenac glucuronide intemediate
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A4 (UGT1A4) DME Info
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000462 Bromfenac Bromfenac metabolite M1 Unclear Bromfenac [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000456 Bromfenac glucuronide intemediate Bromfenac indolinone Unclear Bromfenac [1], [2]
References
1 Metabolite profiling and reaction phenotyping for the in vitro assessment of the bioactivation of bromfenac. Chem Res Toxicol. 2020 Jan 21;33(1):249-257.
2 Metabolic disposition of 14C-bromfenac in healthy male volunteers J Clin Pharmacol. 1998 Aug;38(8):744-52. doi: 10.1002/j.1552-4604.1998.tb04815.x.

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