Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000488)
Formula Reactant Hydroxynorbuprenorphine Product Hydroxynorbuprenorphine glucuronide
Reactant Info Product Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000489 Hydroxybuprenorphine Hydroxynorbuprenorphine Oxidation - N-Dealkylation Buprenorphine hydrochloride [1]
MR000486 Norbuprenorphine Hydroxynorbuprenorphine Oxidation - Oxidation Buprenorphine hydrochloride [1], [2], [3]
References
1 In vitro metabolism study of buprenorphine: evidence for new metabolic pathways. Drug Metab Dispos. 2005 May;33(5):689-95.
2 Interaction between buprenorphine and norbuprenorphine in neonatal opioid withdrawal syndrome. Drug Alcohol Depend. 2023 Jun 21;249:110832. doi: 10.1016/j.drugalcdep.2023.110832.
3 Determination of buprenorphine, norbuprenorphine, naloxone, and their glucuronides in urine by liquid chromatography-tandem mass spectrometry. Drug Test Anal. 2021 Sep;13(9):1658-1667. doi: 10.1002/dta.3104.

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