Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000489)
Formula Reactant Hydroxybuprenorphine Product Hydroxynorbuprenorphine
Reactant Info Product Info
Metabolic Type Oxidation - N-Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000491 Bupivacaine hydrochloride Hydroxybuprenorphine Oxidation - Hydroxylation Buprenorphine hydrochloride [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000486 Norbuprenorphine Hydroxynorbuprenorphine Oxidation - Oxidation Buprenorphine hydrochloride [1], [2], [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000488 Hydroxynorbuprenorphine Hydroxynorbuprenorphine glucuronide Conjugation - Glucuronidation Buprenorphine hydrochloride [1]
References
1 In vitro metabolism study of buprenorphine: evidence for new metabolic pathways. Drug Metab Dispos. 2005 May;33(5):689-95.
2 Interaction between buprenorphine and norbuprenorphine in neonatal opioid withdrawal syndrome. Drug Alcohol Depend. 2023 Jun 21;249:110832. doi: 10.1016/j.drugalcdep.2023.110832.
3 Determination of buprenorphine, norbuprenorphine, naloxone, and their glucuronides in urine by liquid chromatography-tandem mass spectrometry. Drug Test Anal. 2021 Sep;13(9):1658-1667. doi: 10.1002/dta.3104.

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