Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000515)
Formula
SVG example
Hydroxylation
Reactant Bupropion Product R-4'-hydroxybupropion
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000520 Bupropion (2R)-2-(tert-butylamino)-1-(3-chlorophenyl)-3-hydroxypropan-1-one Oxidation - Hydroxylation Bupropion [1]
MR000516 Bupropion R,R-threohydrobupropion Reduction - Ketoreduction Bupropion [1]
MR000518 Bupropion R,S-erythrohydrobupropion Reduction - Ketoreduction Bupropion [1]
MR000519 Bupropion S,R-erythrohydrobupropion Reduction - Ketoreduction Bupropion [1]
MR000517 Bupropion S,S-threohydrobupropion Reduction - Ketoreduction Bupropion [1]
MR000514 Bupropion S-4'-hydroxybupropion Oxidation - Hydroxylation Bupropion [1]
MR000513 Bupropion S-hydroxybupropion Oxidation - Hydroxylation Bupropion [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000504 R-4'-hydroxybupropion R,R-threo-4'-hydroxy-hydrobupropion Reduction - Ketoreduction Bupropion [1]
MR000501 R-4'-hydroxybupropion R,S-erythro-4'-hydroxy-hydrobupropion Reduction - Ketoreduction Bupropion [1]
MR000503 R-4'-hydroxybupropion R-4'-hydroxybupropion glucuronide Conjugation - Glucuronidation Bupropion [1]
MR000502 R-4'-hydroxybupropion R-4'-hydroxybupropion sulfate Conjugation - Sulfation Bupropion [1]
References
1 DrugBank(Pharmacology-Metabolism)Bupropion

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