Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000517)
Formula Reactant Bupropion Product S,S-threohydrobupropion
Reactant Info Product Info
Metabolic Enzyme Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DME Info
Aflatoxin B1 aldehyde reductase member 3 (AKR7A3) DME Info
Metabolic Type Reduction - Ketoreduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000520 Bupropion (2R)-2-(tert-butylamino)-1-(3-chlorophenyl)-3-hydroxypropan-1-one Oxidation - Hydroxylation Bupropion [1]
MR000516 Bupropion R,R-threohydrobupropion Reduction - Ketoreduction Bupropion [1]
MR000518 Bupropion R,S-erythrohydrobupropion Reduction - Ketoreduction Bupropion [1]
MR000515 Bupropion R-4'-hydroxybupropion Oxidation - Hydroxylation Bupropion [1]
MR000519 Bupropion S,R-erythrohydrobupropion Reduction - Ketoreduction Bupropion [1]
MR000514 Bupropion S-4'-hydroxybupropion Oxidation - Hydroxylation Bupropion [1]
MR000513 Bupropion S-hydroxybupropion Oxidation - Hydroxylation Bupropion [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000507 S,S-threohydrobupropion S,S-threo-4'-hydroxy-hydrobupropion Oxidation - 4'-Hydroxylation Bupropion [1]
MR000508 S,S-threohydrobupropion S,S-threohydrobupropion glucuronide Conjugation - Glucuronidation Bupropion [1]
References
1 DrugBank(Pharmacology-Metabolism)Bupropion

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