Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000524)
Formula
CYP3A4 ...
SVG example
N-Oxidation
Reactant Buspirone Product Buspirone N-oxide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - N-Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000523 Buspirone 1-Pyrimidinylpiperazine Oxidation - N-Dealkylation Buspirone [1], [2], [3]
MR000525 Buspirone 3'-hydroxybuspirone Oxidation - Hydroxylation Buspirone [2]
MR000522 Buspirone 5-hydroxybuspirone Oxidation - Hydroxylation Buspirone [4]
MR000526 Buspirone 6'-hydroxybuspirone Oxidation - Hydroxylation Buspirone [2], [3]
References
1 Cytochrome P450 3A-mediated metabolism of buspirone in human liver microsomes. Drug Metab Dispos. 2005 Apr;33(4):500-7.
2 DrugBank(Pharmacology-Metabolism)Buspirone
3 Interaction of buspirone and its major metabolites with human organic cation transporters. Fundam Clin Pharmacol. 2023 Feb 26. doi: 10.1111/fcp.12883.
4 Metabolism and disposition of buspirone Am J Med. 1986 Mar 31;80(3B):41-51. doi: 10.1016/0002-9343(86)90331-1.

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