Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000553)
Formula
SVG example
O-Deethylation
Reactant Candesartan Product O-Deethylated candesartan
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - O-Deethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000554 Candesartan cilexetil Candesartan Hydrolysis - Hydrolysis Candesartan cilexetil [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000552 Candesartan Candesartan N2-glucuronide Conjugation - N-Glucuronidation Candesartan cilexetil [2]
MR000551 Candesartan Candesartan O-glucuronide Conjugation - O-Glucuronidation Candesartan cilexetil [2]
References
1 Different hydrolases involved in bioactivation of prodrug-type angiotensin receptor blockers: carboxymethylenebutenolidase and carboxylesterase 1. Drug Metab Dispos. 2013 Nov;41(11):1888-95.
2 The human UDP-glucuronosyltransferase UGT1A3 is highly selective towards N2 in the tetrazole ring of losartan, candesartan, and zolarsartan. Biochem Pharmacol. 2008 Sep 15;76(6):763-72.

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