Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000554)
Formula
SVG example
Hydrolysis
Reactant Candesartan cilexetil Product Candesartan
Reactant Info Product Info
Metabolic Enzyme Carboxylesterase 1 (CES1) DME Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000552 Candesartan Candesartan N2-glucuronide Conjugation - N-Glucuronidation Candesartan cilexetil [1]
MR000551 Candesartan Candesartan O-glucuronide Conjugation - O-Glucuronidation Candesartan cilexetil [1]
MR000553 Candesartan O-Deethylated candesartan Oxidation - O-Deethylation Candesartan cilexetil [2]
References
1 The human UDP-glucuronosyltransferase UGT1A3 is highly selective towards N2 in the tetrazole ring of losartan, candesartan, and zolarsartan. Biochem Pharmacol. 2008 Sep 15;76(6):763-72.
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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