Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000641)
Formula Reactant Demonomethylchlorpromazine Product Dedimethylchlorpromazine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011383 Chlorpromazine Demonomethylchlorpromazine Unclear - Unclear Chlorpromazine [1]
MR000642 Chlorpromazine hydrochloride Demonomethylchlorpromazine Unclear Chlorpromazine hydrochloride [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011382 Chlorpromazine Dedimethylchlorpromazine Unclear - Unclear Chlorpromazine [1]
References
1 DrugBank(Pharmacology-Metabolism):Chlorpromazine
2 Classics in Chemical Neuroscience: Chlorpromazine ACS Chem Neurosci. 2019 Jan 16;10(1):79-88. doi: 10.1021/acschemneuro.8b00258.
3 Determination of chlorpromazine and its metabolites in animal-derived foods using QuEChERS-based extraction, EMR-Lipid cleanup, and UHPLC-Q-Orbitrap MS analysis. Food Chem. 2023 Mar 1;403:134298. doi: 10.1016/j.foodchem.2022.134298.

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