Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000769)
Formula Reactant Desloratadine Product Desloratadine N-glucuronidation
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 2B10 (UGT2B10) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000770 Desloratadine 5-hydroxydesloratadine Oxidation - Hydroxylation Desloratadine [1]
MR000771 Desloratadine 6-hydroxydesloratadine Oxidation - Hydroxylation Desloratadine [1]
MR006904 Desloratadine Desloratadine glucuronide Conjugation - Glucuronidation Loratadine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000766 Desloratadine N-glucuronidation 3-hydroxydesloratadine N-glucuronide Oxidation - Hydroxylation Desloratadine [2], [1]
References
1 A long-standing mystery solved: the formation of 3-hydroxydesloratadine is catalyzed by CYP2C8 but prior glucuronidation of desloratadine by UDP-glucuronosyltransferase 2B10 is an obligatory requirement Drug Metab Dispos. 2015 Apr;43(4):523-33. doi: 10.1124/dmd.114.062620.
2 Further characterization of the metabolism of desloratadine and its cytochrome P450 and UDP-glucuronosyltransferase inhibition potential: identification of desloratadine as a relatively selective UGT2B10 inhibitor. Drug Metab Dispos. 2015 Sep;43(9):1294-302.

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